Metformin Mechanism of Action & Side Effects (Pharmacology Animation)
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Metformin Mechanism of Action & Side Effects (Pharmacology Animation)
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For over 60 years, we thought metformin worked mainly through the liver and gut. But new research suggests the brain may play a major role too. This study identified a specific brain pathway (Rap1 in the hypothalamus) that appears critical to metformin’s glucose-lowering effects, potentially reshaping how we understand one of the world’s most prescribed diabetes medications. Source: Sci. Adv. 2025;11:eadu3700
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Why is metformin taken with food? A lot of people are told to do this, but not always told why. Taking metformin with food can help reduce stomach side effects like nausea, discomfort, and diarrhoea, which can make it easier to tolerate. Small instruction, big difference. Save this post for later and share it with someone who takes metformin. Comment “metformin” if you want more simple medication explainers. #diabeteseducator #metformin #type2diabetes #diabeteseducation #bloodsugar
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