Chronic kidney disease (CKD) is typically associated with severe fibrosis, the exact pathogenesis of which remains unclear.

Under nutrient-rich conditions, bulk autophagy is inhibited by the action of the nutrient sensor Tor kinase complex 1 (TORC1) (Papinski and Kraft, 2016; Noda and Ohsumi, 1998) TORC1 acts on the ...

N6-methyladenosine (m 6 A) exerts many of its regulatory effects on eukaryotic mRNAs by recruiting cytoplasmic YT521-B homology-domain family (YTHDF) proteins. Here, we show that in Arabidopsis ...

Prostate cancer (PCa) is the second most frequently occurring cancer and the fifth leading cause of cancer mortality among men worldwide in 2022 (Bray et al, 2024).Androgen receptor (AR) is considered ...

Intriguingly, single-cell transcriptome profiling of fetal gonads from both humans and mice shows that MCM8 is also highly expressed in PGCs undergoing rapid mitosis (Li et al, 2017; Niu and Spradling ...

ADHD is a prevalent neurodevelopmental disorder characterized by predominant symptoms in the domains of inattention, hyperactivity, and impulsivity, either individually or combined, and primarily ...

Rheumatoid arthritis (RA) is associated with heart and lung dysfunction. Current therapies fail to attenuate such complications. Here, we identify formyl-peptide receptor type 2 (FPR2) as a ...

In this study, using C. elegans and human cell lines, we characterized the physiological effects of thiol reductive stress. Because thiol antioxidants result in the increased expression of rips‐1 ...

The ubiquitin system is an integral part of cellular responses to environmental changes. The post‐translational modification of proteins with ubiquitin modulates virtually every cellular pathway and ...

Peer ReviewDownload a summary of the editorial decision process including editorial decision letters, reviewer comments and author responses to feedback. Fungal infections and autoimmunity share a ...

Evolution has only explored an infinitesimal portion of the potential protein sequence landscape (Huang et al, 2016).Enormous potential, therefore, exists in unlocking the principles of protein ...

Macrophages not only clean the wound early for repair, but are also critically involved in all subsequent phases of proliferation and regeneration (Mirza et al, 2009; Shook et al, 2016).They ...