In amyotrophic lateral sclerosis and many cases of frontotemporal dementia, the RNA-binding protein TDP-43 abandons the nucleus and clumps up in cytoplasm, disrupting the normal workings of neurons ...
Mutations in the lipid transporter ABCA7 are known to elevate the risk of Alzheimer’s disease, but how they do so has been murky. Now, scientists led by Li-Huei Tsai at MIT in Cambridge, Massachusetts ...
Some evidence suggests that regular consumption of fish, nuts, fruits, veggies, and whole grains, aka the Mediterranean diet, reduces a person’s risk of dementia. APOE4, on the other hand, increases ...
The network provides high-quality brain tissue to scientists and clinicians and supports major initiatives on research into neurological disorders, including the aims of the Ministerial Action Group ...
Sponsor Chan Zuckerberg Biohub Network and the Chan Zuckerberg InitiativeDue Date November 13, 2025 ...
Sponsor Chan Zuckerberg Biohub Network and the Chan Zuckerberg InitiativeDue Date November 13, 2025 ...
This approach uses mesenchymal stem cells isolated from a patient’s own fat tissue to treat neurodegenerative diseases. The stem cells are supposed to assist in repair of damaged tissue and ...
Gotcha! Scientists spot where, and possibly how, p-tau217 first appears in the brain. In a postmortem study of individuals spanning the Alzheimer’s disease spectrum, researchers led by Michiko Sekiya ...
While amyloid immunotherapy is slowly becoming more accepted in clinical use, its biggest drawback remains the risk of ARIA. Scientists continue to study which patients are most at risk, how to ...
Scientists have a new trick to tackle TDP-43: antibodies delivered via adeno-associated virus. In the September 3 Molecular Therapy, scientists led by Damien Nevoltris at AC Immune, Lausanne, ...
Species: Mouse Genes: SNCA Modification: SNCA: Transgenic Disease Relevance: Parkinson's Disease Strain Name: B6;DBA-Tg(Thy1-SNCA)61Ema Genetic Background: (C57BL/6 x DBA/2)F1 (strain of origin) ...
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