Could a single nucleotide switch safeguard decades of brain health before Alzheimer’s sets in? Researchers know that this is what the rare apolipoprotein E3 Christchurch variant does, but how it pulls ...

With several antibodies to mop up amyloid plaques coming into routine use, the big challenge for scientists has become to find ways to temper tau pathology. Two different studies report some news on ...

Polluted air leaves its mark on the brain. In the September 8 JAMA Neurology, Edward Lee and colleagues at the University of Pennsylvania, Philadelphia, report that two decades of autopsies reveal a ...

In amyotrophic lateral sclerosis and many cases of frontotemporal dementia, the RNA-binding protein TDP-43 abandons the nucleus and clumps up in cytoplasm, disrupting the normal workings of neurons ...

Scientists have uncovered a potential new mechanism whereby α-synuclein pathology spreads. Like black holes, large densities of α-synuclein pull in surrounding matter. Among the victims trapped in ...

As the brain ages, many cell types succumb to senescence. How does this start? In the September 10 Nature Aging, scientists led by Wei Cai, Zhengqi Lu, and Quentin Liu at Sun Yat-Sen University, ...

Summary The PS1 P264L knock-in mouse line was derived using a two-step mutagenesis strategy similar to that used to generate the TgAPPSwe-KI line (Reaume et al., 1996). An advantage to this model is ...