Hypertension heightens the risk of Alzheimer’s disease, but exactly how is not understood. In a bioRxiv preprint posted September 19, scientists led by Costantino Iadecola at Weill Cornell Medical ...

This knock-in (KI) mouse model was generated by introducing a D427V point mutation into exon 10 of the mouse Gba1 (glucosidase, beta, acid 1) gene, which corresponds to the human D409V mutation (The ...

The gene PSEN2 encodes presenilin-2, a subunit of γ-secretase, the aspartyl protease responsible for Aβ generation. Missense mutations in PSEN2 are a rare cause of early onset Alzheimer's disease.

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Building 114, Suite 2011 16th Street Charlestown, MA02129 United States Visit Website Contact: Bradley T. Human, M.D., Ph.D. Phone: (617) 726-3987 E-mail: [email protected] Brain Banks Home ...

In September 2016, the Cocoa Supplement and Multivitamin Outcomes Study of Cognition (COSMOS-Mind) began enrolling 2,262 people 65 or older without dementia to evaluate the effect of three years of ...

Whether a person eats a cookie or devours the whole box could come down to the mood of microglia in their hypothalamus. Blocking activation of the region’s NLRP3 inflammasome could keep excessive ...

The brain gets the spotlight when it comes to how it ages but, behind the scenes, the gut microbiome also transforms over time. As microbial communities shift, so do their metabolites—which can leak ...

As Alzheimer’s disease pathology advances, tangles propagate throughout the brain in a fairly stereotypical pattern. Yet tau PET scans of people at the same disease stage are not identical. Could ...

Contact Information Subodh Verma, M.D., Ph.D., FRCSC, FAHA, FCAHS Toronto, CanadaProfessional Information ProfessorUniversity of Toronto ...

For people with cerebral amyloid angiopathy (CAA), the heightened risk of ARIA, i.e., inflammation around blood vessels, may outweigh any potential gains of anti-amyloid immunotherapy. But with about ...

The human brain develops over decades, making this process notoriously difficult to model in a dish. Now, scientists have taken a step toward this goal. As described in preprint posted October 2 on ...