Hemophagocytic lymphohistiocytosis (HLH) is a well-recognised complication of systemic lupus erythematosus (SLE). In one small case series, HLH was noted in approximately 5% of patients with lupus. 1 ...

Despite advancements in lupus management over the past two decades, infection remains a significant cause of morbidity and mortality among patients with systemic lupus erythematosus (SLE). 1 2 Various ...

Bone involvement is a common cause of morbidity and disability in systemic lupus erythematosus (SLE). 1 This is both a consequence of the disease itself and treatments, including steroids.2 As ...

Systemic lupus erythematosus (SLE) is a clinically and immunologically heterogeneous autoimmune disease that can be challenging to diagnose, especially in its early stages. Although developed in the ...

Clinicians remain believers in B-cell depletion despite the failure of rituximab in the EXPLORER, LUNAR, and BELONG clinical trials. 1–3 Additional studies suggested that the B-cell depletion that ...

Background Elevated levels of interferons (IFN) are a hallmark of Systemic Lupus Erythematosus (SLE) and have been linked to disease flares, but the precise mechanisms by which this occurs remain ...

Background Persistent production of type I interferons (IFN-Is) is one of the hallmarks of lupus skin disease that is exacerbated by ultraviolet (UV) light. We previously showed IFN-I induction by UV ...

Conclusions Voclosporin was well-tolerated over three years of treatment. The significant reductions in proteinuria initially achieved in AURORA 1 were maintained throughout AURORA 2 and more patients ...

Background Lupus is a complex autoimmune disease characterized by loss of self-tolerance, leading to dysregulated functions of T and B cells. Broadly increased glucose metabolism has been reported in ...

Background/ Purpose Systemic lupus erythematosus (SLE) is an autoimmune disease with heterogeneous manifestations across patient populations. Although real-word evidence data on SLE exists via SLE ...

Background/ Purpose Nephritis is one of the most severe manifestations in lupus, affecting 40–70% of patients. Though immune targeted therapies have improved, a significant number of patients ...

Conclusion The 10 th Century Bishop of Liège, Eraclius, is the first person described as having a disease called lupus, which had ulcers resembling the bites of a wolf and would ‘wolfishly’ devour ...