This is an important study utilizing innovative CRISPR based approaches demonstrating the role of the KLF family of transcription factors in the post natal maturation of cortical projection neurons.

Background Evaluation of the structural integrity and functional excitability of the corticospinal tract (CST) is likely to be important in predicting motor recovery after stroke. Previous reports are ...

Targeting the pyramidal tract neurons and their specific serotonin 5-HT2A receptor ... the drug was essentially ineffective – proof that this cell type and its pathway, which extends from the frontal ...

Given the connections between frontal and temporal regions, these anatomical pathways may serve to integrate ... prefrontal cortex via the UF and EmC tracts, and is involved in the mapping of ...

However, the biomolecular pathways triggered by mechanical stimuli in the nervous system has not been fully explored, especially compared to other body systems. This gap in knowledge may be due to the ...