Rapidly mutating DNA regions were mapped using a multi-generational family and advanced sequencing tools. Understanding how ...

Werner syndrome ATP-dependent helicase (WRN) is an enzyme involved in DNA replication and repair and has been identified as a synthetic lethality target in tumors with high microsatellite instability ...

Scd6 genetically interacts with SRS2, a DNA helicase with an anti-recombination role in DNA ... by cellular conditions and/or exogenous factors leads to genomic instability. Replication errors, ...

Also, the authors have not compared the recently published Cryo-EM structures of the metazoan CMG helicases with their predicted models ... of CMG formation during the rate-limiting step of DNA ...

The initial step in eukaryotic DNA replication is the assembly of the pre-initiation complex, including the formation of two head-to-head hexameric helicases around the replication origin. How these ...