For decades, the biology of the intestinal stem cells was considered analogous to that of well-studied hematopoietic stem ...

The necrosome is the key macromolecular signaling platform initiating necroptosis, i.e., a RIPK1/RIPK3-dependent program of cell death with an important role in the control of inflammation in ...

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While SMAD7 has been widely studied in liver and kidney fibrosis—where it dampens TGF-β activity and restrains inflammation-driven ECM accumulation—recent evidence highlights its relevance in cardiac, ...

Several bacterial species have been implicated in the development of colorectal carcinoma (CRC), but CRC ‐associated changes of fecal microbiota and their potential for cancer screening remain to be ...

NF2 deficiency eliminates LATS-mediated phosphorylation of YAP, allowing dephosphorylated YAP to enter the nucleus and co-activate CAD and DHODH transcription. Together, these enzymes accelerate de ...