Tda1 protein kinase, activated by Snf1 and yeast GSK3-β, fine-tunes metabolism through the phosphorylation of Hxk2, which is ...

Protein Kinase A (PKA) is regulated spatially and temporally via scaffolding of its catalytic (Cα) and regulatory (RI/RII) subunits by the A-kinase-anchoring proteins (AKAP). By binding to an AKAP11 ...

Disease-modifying treatments for major neurocognitive disorders, including Alzheimer’s disease, Parkinson’s disease and other cognitive deficits, are among the main unmet needs in modern medicine.

The development of new artificial biomaterials for bone defect repair is an ongoing area of clinical research. Metal ions such as zinc, copper, magnesium, calcium, strontium, silver, and cerium play ...

Department of Chemical Engineering and Biotechnology, University of Cambridge, Philippa Fawcett Drive, Cambridge CB3 0AS, U.K. Department of Chemistry, University of Cambridge, Cambridge CB2 1EW, U.K.

It has been shown that GDM leads to mitochondrial dysfunction in placental endothelial and trophoblast cells, especially reduced mitochondrial F0F1-ATP synthase (complex V) activity, which reduces ...

Inside the cell, the thioester, coenzyme A (CoA) is added to the fatty acid by fatty acyl-CoA synthase (FACS), forming long-chain ... the uptake and phosphorylation of glucose and to a reduced ...

Hepatocellular carcinoma Fatty acid synthase Cholesterol biosynthesis HMG-CoA reductase Systems biology This is an open access article distributed in accordance with the Creative Commons Attribution ...

Analogues of the natural glucagon-mimetic Glucagon-Like Peptide-1 (GLP-1) reduce body mass and help to prevent type-2 diabetes mellitus and cancer development, partly by inhibiting glycogen synthase ...