Multiple preseason injuries created serious questions about San Francisco’s offensive line stability and backfield depth heading into Week 1.

The one 49ers player who was perhaps hardest hit by the ravenous injury bug was running back Christian McCaffrey. He suffered a calf strain and Achilles injury during training camp that forced him to miss the first eight games of the schedule,

Given the injury problems the 49ers currently face with their two starting receivers, Jauan Jennings and Brendon Aiyuk, Purdy may have to rely on Kittle as a primary target this season. With Ricky Pearsall entering his sophomore season, lingering uncertainty about his inexperience could increase the team’s reliance on Kittle.