Volume 17, Issue 4, on April 2, 2025, titled "Fisetin ameliorates vascular smooth muscle cell calcification via DUSP1-dependent p38 MAPK inhibition." ...

Using human and mouse study models ... candidate for slowing or preventing vascular calcification. The findings could have broad implications for aging populations and individuals with kidney ...

Fisetin treatment suppressed calcific marker expression and calcification of VSMCs as well as p38 MAPK phosphorylation induced by pro-calcific ...

Investigators have discovered a new pathway that may lead to a treatment for high blood pressure and aortic aneurysms. By creating a new laboratory model for studying these conditions, the team ...

To investigate, Michel and his colleagues created a transgenic mouse ... vascular disease states associated with oxidative stress, including Alzheimer's disease, atherosclerosis, and aging." ...

Oxidative stress can occur when our cells are exposed to harmful molecules called "reactive oxygen species" over time. These reactive oxygen species can damage cells and are found in important disease ...

Investigators at Mass General Brigham have discovered a new pathway that may lead to a treatment for high blood pressure and aortic aneurysms. By creating a new laboratory model for studying these ...

Oxidative stress can occur when our cells are exposed to harmful molecules called "reactive oxygen species" over time. These reactive oxygen species ...

In 2025, Nicotinamide Mononucleotide (NMN) is making significant waves in the health and longevity sectors, quickly becoming one of the most sought-after supplements for those looking to boost energy ...

Among other accomplishments, his hypothesis of vascular normalization reshaped ... how telomere dysfunction links cancer and aging. His mouse models established concepts such as tumor maintenance ...