Both physiologic and non-physiologic side effects can be the basis for ACE ... (such as an excessive increase in serum creatinine concentration) is the basis for drug discontinuation, there ...

If the inhibitor by itself possessed little or no antibacterial action, a synergistic combination would result – that is, the biologic effect ... of the enzyme than the hydrolyzable substrate ...

provides valuable mechanistic insights into the conformational dynamics of Insulin Degrading Enzyme ... substrate. Here, we present five cryoEM structures of the IDE dimer at 3.0-4.1 Å resolution, ...

Next, 3.0 μL of 320 U/mL mTG was added for a final concentration of 8 U/mL ... mTG specifically catalyzes the reaction between a primary amine substrate and Q295 located on the heavy chain. Therefore, ...

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions—but there is always room ...

Inside cells, two important enzymes act like small central regulatory hubs: dipeptidyl peptidase 8 and 9—DPP8/9 for short.

A research team led by Dr. Martin Mollenhauer from the Heart Center at University Hospital Cologne has investigated the link ...

Genome editing has advanced at a rapid pace with promising results for treating genetic conditions -- but there is always room for improvement. A new paper showcases the power of scalable protein ...

A research team at the Institute for Basic Science (IBS) has identified a previously unknown enzyme, SIRT2, that plays a key ...

Experts weigh in on the best supplementals to help to break down protein, fats, and carbohydrates into simpler compounds that ...