A recent study identifies Neural EGFL-like 2 (NELL2), a secreted protein, as a key regulator of bone homeostasis, offering ...

Here’s what a bunch of doctors actually think about TikTok’s latest health anxiety — and what they do about it IRL.

But there’s a silent side effect of estrogen loss that might be the most dangerous—and overlooked—one of all: bone density ...

They stimulate the activity of osteoblasts (bone-building cells) while helping regulate osteoclasts (cells that break down bone), maintaining the delicate balance needed for strong, healthy bones.

interact indirectly and directly with important groups of bone cells involved in the bone turnover process (including osteoclasts, osteoblasts and osteocytes) by stimulating the process of bone ...

Bisphosphonates are synthetic analogs of pyrophosphate that deposit on the surface of bone, where they are phagocytosed by osteoclasts and have an antiresorptive effect. This class of drug has a ...

New research highlights myostatin inhibition as a powerful strategy to combat osteoporosis and sarcopenia. Learn how ...

Importantly, RANKL and RANK are essential for the development and activation of osteoclasts and bone loss in response to virtually all triggers tested. Therapeutically, inhibition of RANKL function ...

Objectives The aim of this study is to reveal the role of ORM2 in the differentiation and function of osteoclasts and osteoblasts. Methods To determine the effect of ORM2 on RANKL-induced osteoclast ...

Second, OCN influences the differentiation and activity of osteoclasts and regulates bone resorption through its interaction with specific receptors, such as GPRC6A (Wang H. et al., 2021).