Pain and temperature stimuli activate neurons of lamina I ... All 12 fusiform cells were nociceptive-specific, responsive only to pinch and/or heat. All 11 pyramidal cells were thermoreceptive ...

They found that in addition to sensitizing touch receptors as expected, the mutations made nociceptive receptors—neurons that detect painful mechanical stimuli—dramatically more sensitive to ...

Experiments in fruit fly larvae show that epidermal cells can communicate with sensory neurons to drive responses to pain.