Homologous recombination (HR) is an important process that plays multiple crucial roles during meiosis, a type of cell cycle dedicated to sexual reproduction. During HR, homologous DNA molecules ...

Recombination between homologous chromosomes is essential for successful meiosis. It drives genetic diversity in germline cells and provides the necessary scaffolding for accurate, balanced ...

Homologous recombination DNA repair deficiency (HRD) is associated with sensitivity to platinum and poly (ADP-ribose) polymerase inhibitors in certain cancer types, including breast, ovarian, ...

The Association for Molecular Pathology announced the publication of best practice recommendations for clinical laboratories developing and performing homologous recombination deficiency (HRD) testing ...

Poly(ADP-ribose) polymerase inhibitors (PARPi) have shown promising clinical results in the treatment of ovarian cancer. Analysis of biomarker subgroups consistently revealed higher benefits for ...

Radiation therapy remains one of the most widely deployed weapons in oncology, yet its effectiveness is routinely undermined by a frustrating biological reality: many cancer cells are simply better at ...

When DNA breaks, cells must repair it accurately to prevent harmful mutations. Researchers have discovered that during a key repair process called homologous recombination, the cell uses loops in its ...

According to a research published in Oncogene recently, a team led by Prof. Zhao Guoping from Hefei Institutes of Physical Science (HFIPS), Chinese Academy of Sciences (CAS) found, for the first time, ...

【日程发布】第七届单细胞与空间组学论坛9月15日，浙江大学研究团队在期刊《MedComm》上发表了研究论文，题为“Cooccurrence of Homologous Recombination Deficiency and Mismatch ...

DSBs are more likely to occur in some genomic regions than others. Elucidating mechanisms shaping the DSB “landscape” requires identifying the biochemical factors involved, understanding how they ...