In many cases, diagnosing hereditary spastic paraparesis is not a straightforward process. Diagnosis may be based, in part, on a family history of the disease. But if a person's family medical history ...

Hereditary spastic paraplegia (HSP), also known as familial spastic paraparesis, is a term used for a group of inherited diseases that affect the upper motor neurons traveling from the brain through ...

There is no cure for the rare disease Hereditary Spastic Paraplegia (HSP), but researchers from Drexel University's College of Medicine and the UMass Chan Medical School have achieved ...

CAMBRIDGE, Mass (April 11, 2011)—In a research collaboration blind to affairs of politics, ethnicity, and religion, an international team led by Israeli scientists has identified the genetic cause of ...

Familial pure dominant spastic paraplegia (SPG) is a clinically and genetically heterogeneous group of neurodegenerative disorders, mainly characterised by spasticity of the lower limbs. Gait ...

Although huge strides have been made in the past 30 years in linking pathogenic genetic variants to Mendelian disorders, many rare diseases remain genetically unresolved. In a new study, an innovative ...