Taste, pain, or response to stress—nearly all essential functions in the human body are regulated by molecular switches ...

Sterols, such as cholesterol in our bodies or ergosterol in yeast cells, are among the most abundant lipids in eukaryotic ...

Viruses are natural delivery systems for nucleic acids, but they have several significant drawbacks: They aren’t targeted to any one cell type, for instance, and they can’t be re-dosed—the ...

Unlike glucocorticoid agents ... Clearance mechanisms not based on FcRn, such as the asialoglycoprotein receptor, T-cell mediated cytotoxicity, or classical FcγRs, may limit the response to ...

Others might bind to a CB2 receptor in your immune cells to signal that your body’s experiencing inflammation, a common sign of autoimmune disorders. The ECS is complicated, and experts haven ...

In high-grade DCIS cells, they observed that cell crowding led to an increase in the number of various proteins on the plasma membrane of the cells. In particular, there was a striking 153-fold ...

In most patient tumors, resistant cancer cells increased ERBB growth pathway activity during treatment, only partially through ERBB receptor upregulation. Concurrently, fibroblasts within the tumor ...

Neurotrophin (NT) receptor signaling regulates neuronal ... between active and inactive states of bitopic membrane proteins. (81−83) Thus, considering that the phospholipid bilayers better represent ...

Structural studies of membrane proteins historically have relied almost exclusively on first removing membrane proteins from the membrane with dispersive agents like detergents. But dispersive agents ...

Discussion: Overall, these results support the involvement of PXR in the regulation of testosterone homeostasis in mouse Leydig cells and open new avenues of research into the involvement of this ...