While scientists have long understood the importance of helicases in DNA replication, the precise coordination between DNA, helicases, and ATP remained unclear. “They did not know how DNA ...

Our lab studies the mechanism of eukaryotic chromosome replication. Chromosomes are the carriers of the genetic and epigenetic information and faithful chromosome replication is of fundamental ...

Werner syndrome ATP-dependent helicase (WRN) is an enzyme involved in DNA replication and repair and has been identified as a synthetic lethality target in tumors with high microsatellite instability ...

Cell division is the process by which a parental cell gives rise to two daughter cells. The process involves both nuclear division and cytokinesis and can either produce two equal cells (symmetric ...

The origin recognition complex (ORC) is an essential loading factor for the replicative Mcm2-7 helicase complex. Despite ORC's critical role in DNA replication, there have been instances where the ...

Scd6 genetically interacts with SRS2, a DNA helicase with an anti-recombination role in DNA ... by cellular conditions and/or exogenous factors leads to genomic instability. Replication errors, ...

WRN is a DNA helicase required for DNA replication and DNA repair and is a validated synthetic lethal target for tumors with microsatellite instability (MSI). MSI is a phenotypic consequence of ...

This shift would transform real-world disease management and improve patient quality of life. HPIs target a distinct step in HSV DNA replication. In vitro results show that ABI-5366 has low nanomolar ...

Finally, we provide supporting in silico evidence of a novel heterozygote advantageous variant in the chromodomain helicase DNA binding protein 6 gene (CHD6; involved in influenza virus replication).

Researchers utilized recently published telomere-to-telomere genomes of humans, chimpanzees, bonobos, gorillas, and two ...

Rapidly mutating DNA regions were mapped using a multi-generational family and advanced sequencing tools. Understanding how ...