The international team used cryo-electron microscopy to observe a helicase, an enzyme essential for DNA replication. This work reveals a mechanism far more subtle than previously imagined ...

While scientists have long known the importance of helicase in DNA replication, "they did not know how DNA, helicases and ATP ...

that requires us to understand the molecular architecture of DNA helicase. Coordination of DNA Unwinding and Replication is Essential Why is coordination between DNA unwinding and synthesis important?

Replication is the process by which a double-stranded DNA molecule is copied to produce two identical DNA molecules. DNA replication is one of the most basic processes that occurs within a cell.

Werner syndrome ATP-dependent helicase (WRN) is an enzyme involved in DNA replication and repair and has been identified as a synthetic lethality target in tumors with high microsatellite instability ...

During DNA replication, special enzymes move up along the DNA ladder, unzipping the molecule as it moves along. New nucleotides move in to each side of the unzipped ladder. The bases on these ...

precatenanes form along DNA segments that are under positive helical tension (overwound). The presence of precatenanes behind replication forks in vivo implies that replicative helicases generate ...