Each step in the metastatic cascade is rich in biological targets and mechanistic pathways. Given the clear prevalence and clinical significance of bone metastases, understanding of the mechanisms ...

While these events occur far from the eventual site of bone metastasis formation, they are critical steps in the metastatic process that impose significant selective pressure on tumor cells.

In medicine, its ability to produce custom-made, complex structures is changing the way doctors treat injuries and diseases—especially when it comes to rebuilding bones and other body tissues.

Metastasis is the spread of cancer to a part of the body distant from the original primary cancer. This occurs through the transfer of malignant or cancerous cells via lymph or blood. The new ...

Bone metastases are a significant clinical problem in many major cancers, especially in breast and prostate cancer where 70-90% of advanced patients develop bone metastases. Myeloma bone disease is ...

ProPublica is a nonprofit newsroom that investigates abuses of power. Sign up to receive our biggest stories as soon as they’re published. Leer en español. These highlights were written by the ...

Department of Polymeric Materials, School of Materials Science and Engineering, Tongji University, 4800 Caoan Road, Shanghai 201804, China Department of Gynaecology and Obstetrics, Shanghai Key ...

Abstract: Single-photon emission computed tomography (SPECT) is a vital technology for diagnosing bone metastases and other skeletal diseases, playing a critical role in the early diagnosis and ...

Figure 2: Schematic diagram illustrating experimental design to evaluate AXL inhibition in the growth and metastasis of tumors in bone using PCa PDX. We found that batiraxcept significantly reduced ...

A long-term calcium deficiency can lead to dental changes, cataracts, alterations in the brain, and osteoporosis, which causes the bones to become brittle. However, calcium deficiency may cause no ...