Dopaminergic progenitor survival and maturation are also dependent on trophic factors secreted locally by cells in the striatum and substantia nigra, including GDNF and BDNF. One approach to improving ...

Parkinson's disease is characterized by the degeneration of dopamine-producing neurons in the substantia nigra pars compacta ... to dopamine depletion in the striatum and motor symptoms like ...

They found there was inflammation and brain damage in the striatum following the stroke, which they had expected. What the researchers didn’t expect was the impact on another area of the brain, the ...

It is characterised by progressive degeneration of the dopaminergic neurons of the substantia nigra pars compacta (SNpc), which reduces the levels of dopamine available for neurotransmission in the ...