Suppressing OGDH in intestinal stem cells increased αKG levels and drove commitment toward the secretory lineage without causing cell death. Supplementation with a cell-permeable αKG analog ...

Cells can be reprogrammed, edited and differentiated into a wide variety of iPSC-derived cell types and 3-dimensional human cell models. iPSCore™ incorporates extensive characterization ...

A research team led by Professor Takuya Yamamoto (Department of Life Science Frontiers) and Professor Yasuhiro Yamada at the University of Tokyo has developed a novel in vivo system that reveals how ...