Osteogenesis imperfecta (OI) is a heterogeneous connective tissue disorder characterized by brittle bones. Four clinical subtypes are recognized, including a mild (type I), a lethal (type II), a ...

Osteogenesis imperfecta can result in more severe complications. Signs and symptoms range from mild to severe.[1-3] There are eight types of OI, and the categorization is usually based on the ...

Both Jay and Pamela were born with osteogenesis imperfecta Type 3 (OI), which the Cleveland Clinic describes as a "genetic disease that makes your bones thin and brittle." Pamela, 30, and Jay ...

A proband with osteogenesis imperfecta (OI) type III/IV was born to clinically normal parents, who subsequently had two pregnancies terminated because of OI in the fetuses. Cultured fibroblasts ...