A single base change can create a devastating genetic disorder or a beneficial adaptation, or it might have no effect. How do mutations happen ... nucleotides in the human genome, and scientists ...

The research, published yesterday (September 8) in Science, finds that the modern human and the archaic Neanderthal versions of the gene that codes for the protein transketolase-like 1 (TKTL1) differ ...

In attempting to engineer a genetic mouse model for a human disorder, for example, it is important to know what kind of mutation causes the disease (for example, is the disease null, hypomorphic ...