Summary. Doripenem, a member of the β-lactam class of antibiotics, is the newest addition to the carbapenems. It exhibits concentration-independent bactericidal activity against gram-positive ...

Infectious diseases specialist warns of antibiotic misuse leading to drug resistance, urges strict regulation for newer ...

These pathogens are certain types of harmful bacteria called Gram-negative bacteria that are resistant to a strong group of antibiotics called carbapenems, including a specific one named meropenem.

Despite that, GSK has high hopes for Blujepa and two other anti-infective candidates in its pipeline – oral carbapenem antibiotic tebipenem and antifungal Brexafemme (ibrexafungerp ...

The FDA rejected an approval filing back in 2022 that would have made tebipenem the first oral carbapenem-class antibiotic used in complicated urinary tract infections. GSK then swooped in to ...

baumannii were resistant to multiple antibiotics, with most resistant to carbapenems - the drugs of choice for the treatment of A. baumannii infections. Publishing their findings in ...

further increases the threat of antibiotic resistance, according to a GlobalData analyst. The FDA delivered a blow to Spero's hopes of bringing the carbapenem to market in a complete response ...

When a critically ill patient fails to respond to treatment, doctors often turn to their last resort drugs, one of which is ...

They found that lariocidin was effective at killing multidrug- and carbapenem-resistant strains ... of gold in looking for new ribosome-directed antibiotics that are actually quite novel, and ...

By disrupting the cell envelope, saccharin was shown to re-sensitize carbapenem-resistant A. baumannii to antibiotics like meropenem (Fig. 6C). Additionally, it can disrupt preformed biofilms of ...

Oral Presentation: Efficacy and safety in a Phase 2 study of intravenous BV100 combined with polymyxin B versus best available therapy in adult subjects with ventilator associated bacterial pneumonia ...

a All were multicenter, multinational, randomized trials. ITT = intention to treat, VAP = ventilator-associated pneumonia, cIAI = complicated intraabdominal infection, NR = not reported or not ...