To establish whether molecules other than scFv antibody fragments could be lipid-modified and inserted into cell membranes, we cloned the gene encoding human interleukin-2 (IL-2) into vector pLP2 ...

The majority of active development programs are for scFv molecules (n = 10, 53%), of which 80% are for treatment of cancer. Four Fabs, three miniaturized antibodies, one miniaturized scFv ...

Examples of antibody sequences accepted: variable region sequenced from hybridoma, hits (Fab or scFv) selected from display library based method, sequences from single B cell and/or repertoire ...

In a long-term collaboration, we have created a novel method of converting nonneutralizing anti-HIV-1 envelope single chain Fv (scFv) antibody fragments into neutralizing scFvs by targeting expression ...

A modified, smaller version of the antibody (scFV) was found to be equally effective, blocking fertilization in 100% of IVF tests with mouse eggs. Because it lacks the immune-triggering Fc region ...

Illustration of three-step DOTA-PRIT based on targeting with an IgG-scFv bispecific antibody (e.g., huA33-C825 for detection and treatment of colorectal cancer) with dual specificity for a ...

We have developed epitope libraries by phage-display from lymphocytes of patients with these antibodies and thrombosis. We are isolating recombinant scFv fragments to determine their epitope ...

Expressing recombinant antibodies in mammalian cells is essential when post-translational alterations and proper folding are required for downstream applications. The most common problems of ...