Patients do not typically transition to an upper motor neuron bladder or bowels Bladder and bowel anal-rectal sphincter remains flaccid, becomes highly complaint and is characterized by underactivity ...

there are different types of Motor Neuron Diseases which include; Amyotrophic lateral sclerosis (ALS) It was formerly known as Lou Gehrig's disease and can affect the upper and/or lower motor neurons.

Multiple models have been proposed for the mechanism by which mutant superoxide dismutase 1 induces motor neuron death and ... selective degeneration of upper and lower motor neurons, initiating ...