Two-photon microscopy is a type of fluorescence microscopy that, rather than exciting the sample with a single photon, makes use of multiple photons. The advantage over more traditional one-photon ...

Two-photon microscopy (TPM) has revolutionized the field of biology by enabling researchers to observe complex biological processes in living tissues at high resolution. In contrast to traditional ...

Researchers have developed a new two-photon fluorescence microscope that captures high-speed images of neural activity at cellular resolution. By imaging much faster and with less harm to brain tissue ...

Intravital brain imaging is a valuable tool for studying neurons, glial cells, and their surroundings in living animals. It allows the investigation of neurological illnesses, therapeutic efficacy, ...

During an antibody response, sites of massive cell death arise in the germinal centers of lymph nodes. One of the macrophage cell types, tingible body macrophages (TBMs), help with apoptotic cell ...

Cells In A New Light By combining the sensitivity of fluorescent dyes with optical systems that can detect colorful but low-intensity fluorescent light, researchers in many life sciences are able to ...

In PhotoniX, researchers report a self-supervised deep learning method that denoises dynamic fluorescence images in vivo without requiring clean training data. The figure shows in vivo venule images ...

Unlike most organic fluorophores, which typically measure below 1 nm, nanomaterials range between 1 and 100 nm, allowing them to function as distinct entities with a loadable surface. The success of ...

In-vivo imaging of the neuronal activity in mouse primary visual cortex. Left, high-resolution neuronal map; middle, high-speed neuronal activity recording captured by the two-photon microscope with ...