The African turquoise killifish lives in ephemeral ponds in Zimbabwe and Mozambique. To survive the annual dry season, the fish's embryos enter a state of extreme suspended animation or "diapause" for ...

Studying aging and its associated diseases has been challenging because existing vertebrate models (e.g., mice) are relatively long lived, while short-lived invertebrate species (e.g., yeast and worms ...

Aging and neurodegeneration are both known to disrupt the production of functional proteins in cells—a process called "proteostasis," or protein homeostasis. Brain cells in particular fall prey to ...

The study of therapies and interventions to expand healthy human lifespan has been limited by a lack of animal models: traditional vertebrate models such as the mouse live too long to get rapid ...

A central challenge in experimental aging research is the lack of short-lived vertebrate models for genetic studies. Here we present a comprehensive protocol for efficient genome engineering in the ...

Our immune system protects the body from infections and harmful changes throughout our lives. However, it loses its effectiveness with age, resulting in an increased risk of disease. But what happens ...

But scien­tists say Africa’s tragic­ally transient “turquoise killi­fish” could harbour the secret to a long life. Biologists from Stanford University in California have found that three “ageing genes ...

The Turquoise killifish (Nothobranchius furzeri) is the shortest-lived vertebrate that can be kept under laboratory conditions. It exemplifies a rapid growth and aging in fast motion. Now, researchers ...

Turquoise killifish genomes help to explain their 'live fast, die young' lifestyle. You have full access to this article via your institution. For the turquoise killifish, ‘live fast, die young’ is no ...

Turquoise killifish is able to suspend its development for longer than its average lifespan The curious ability of the African turquoise killifish to press pause on its development could have ...