The Hedgehog pathway is an evolutionarily conserved developmental signaling pathway involved in body patterning and the regulation of adult stem cells 1. Perturbations in the Hedgehog pathway are ...
Shanghai Scientists Decipher the Multi-domain Full Length Structure of the Human Smoothened Receptor
SHANGHAI, May 17, 2017 /PRNewswire/ -- A team of scientists led by the iHuman Institute of ShanghaiTech University in collaboration with Fudan University has determined the high-resolution crystal ...
Proceedings of the National Academy of Sciences of the United States of America, Vol. 106, No. 51 (Dec. 22, 2009), pp. 21666-21671 (6 pages) Stimulation by the extracellular Hedgehog (Hh) protein ...
A crystal structure of the human Smoothened (SMO) receptor — an essential component of the Hedgehog signalling pathway — bound to an antitumour compound is reported for the first time. Remarkable ...
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