This retrospective study involved 126 patients with adrenal or extra-adrenal pheochromocytomas, including 24 patients with a family history of multiple endocrine neoplasia 2, von Hippel-Lindau disease ...

The database of the Laboratory for Diagnostic Genome Analysis (LDGA) of the Leiden University Medical Center (LUMC) was used to identify asymptomatic carriers of a known mutation in SDHD or SDHB.

Peripheral blood from unrelated, consenting registry patients with pheochromocytoma was tested for mutations of RET, VHL, SDHD, and SDHB. Clinical data at first presentation and follow-up were ...

Routine hematoxylin and eosin staining is shown on the left of each panel, and IHC staining to detect SDHB is shown on the right of each panel. As shown in Panel A, specimens obtained from the ...