MYC‑driven tumors silence innate immune alarms by clearing R‑loop–derived signals, exposing a new therapeutic angle for targeting MYC without broad inhibition.

Changes in genes have been linked to the development of different diseases for a while. However, it's not exactly clear what ...

This new review article highlights the pivotal and paradoxical role of R-loops in maintaining genomic stability while simultaneously posing risks to it. These three-stranded nucleic acid structures, ...

This study is achieved by Professor Wei Xu’s research team from Agricultural Genomics Institute at Shenzhen, Chinese Academy of Agricultural Sciences. The research team established mDRIP-seq, a ...

A research team at The University of Osaka revealed that the loss of heterochromatin can cause a chain reaction leading to ...

Researchers from The University of Osaka reveal that genetic changes following the loss of heterochromatin can lead to ...

Kyle Miller and his team discovered a potential new target for drug therapies: structures in our DNA called R-loops. A human cancer cell that overexpresses the enzyme APOBEC3B (left) has fewer R-loops ...

New research reveals how the RapA enzyme protects against R-loop cytotoxicity in E. coli. Genetically speaking, it's a bacterium's worst-case scenario: during transcription, newly minted RNA sticks to ...

A study of newly created databases of medulloblastoma has found that patients with tumors containing circular extrachromosomal DNA -- loops of DNA found outside of regular chromosomes -- are twice as ...