"Our research demonstrates that autophagy isn't just about clearing damaged mitochondria or protein aggregates," explained ...

Over the past decade, researchers at RIKEN Center for Developmental Biology in Japan have generated complex tissues, including mouse retinas and Purkinje cells (a type of neuron) that integrated ...

In this case, we combine electrophysiology, multi-photon imaging, and biophysical modeling to understand the computational function of changes in intrinsic excitability in cerebellar Purkinje cells.

“And also trying to unravel a little bit of the cellular mechanisms that were at play here.” To model ataxia, the team selectively silenced Purkinje cells in mice, which caused ataxia-like motor ...