The BK polyomavirus exhibits tropism for the renal tubular epithelium, where it establishes latent infection. Vigorous immunosuppression of renal allograft recipients can lead to reactivation of the ...

A benign virus normally found in the skin can lead to a type of rare, lethal skin cancer. Specifically, infection by the Merkel cell polyomavirus can lead to Merkel cell carcinoma in ...

In a prospective study of patients with stages I-III Merkel cell carcinoma (MCC), seropositivity for rising polyomavirus oncoprotein antibody titers conferred a 58% risk for recurrence at 12 months, ...

From July 2001 to April 2004, we used leflunomide as the initial antiviral therapy in 17 patients with biopsy-proven BK nephropathy. All but one of these patients was receiving tacrolimus, prednisone, ...

Chris Buck stands barefoot in his kitchen holding a glass bottle of unfiltered Lithuanian farmhouse ale. He swirls the bottle gently to stir up a fingerbreadth blanket of yeast and pours the turbulent ...

CANTON, Mass.--(BUSINESS WIRE)--Orthogon Therapeutics, a developer of novel antiviral medicines, today announced the closing of an oversubscribed financing round, exceeding its $5M target and bringing ...

A new study identifies the means by which the JC Polyomavirus enters host cells. It's a particular subset of serotonin receptors. For more than a decade the research group of Brown University ...

BK polyomavirus, or BKPyV, is a major cause of kidney transplant failure. There are no effective drugs to treat BKPyV.

Polyomaviruses typically infect a single species and limited types of tissue. Examples include the human BK and JC viruses and simian virus 40 (SV40). These three viruses are approximately 70 percent ...