Morphine has long been the cornerstone of treatment for moderate-to-severe chronic pain, but its usefulness is undermined by ...

Pain is easy to understand until it isn't. A stubbed toe or sprained ankle hurts, but it makes sense because the cause is clear and the pain fades as you heal. But what if the pain didn't go away?

Deep at the base of the brain, a tiny cluster of nerve cells serves as the body's natural pain reliever, dialing down pain signals traveling up the spinal cord. But nerve damage can flip this system ...

Touch a hot plate and your hand flies back. While the response is almost instant, researchers are still working to better understand the molecular mechanisms behind these sensations of heat and pain.

The ability to accurately detect heat and pain is critical to human survival, but scientists have struggled to understand on a molecular level exactly how our bodies sense these potential risks. Now, ...