Internal bleeding is another major complication of hemophilia, especially in the knees, elbows, or ankles. Chronic joint bleeding can lead to long-term damage, making movement harder over time.

To understand what causes hemophilia it is important to learn about chromosomes. What are chromosomes? Chromosomes are blocks of DNA (deoxyribonucleic acid).

Kasirye says there are two main types of hemophilia; Hemophilia A, which is as a result of Factor VIII deficiency and majority of patients fall under this category, accounting for between 75-80% ...

Just to give listeners a little bit of background, we have two types of hemophilia, hemophilia A and hemophilia B. Hemophilia A is much more common, affects about 150,000 people worldwide.

However, people with hemophilia have low levels of either factor VII or factor IX. Hemophilia could also result in bleeding within joints which can then lead to chronic joint disease and pain.

All previously discovered FIX mutations lead to hemophilia, the opposite of thrombosis. FIX-Padua is hyperfunctional—it clots blood 8 to 12 times more strongly than normal, wild-type factor IX.