Patients do not typically transition to an upper motor neuron bladder or bowels Bladder and bowel anal-rectal sphincter remains flaccid, becomes highly complaint and is characterized by underactivity ...

Motor neurone disease (MND) is a progressive and, as yet, incurable illness that results in gradual paralysis and death ... brain to the spinal cord and the lower motor neurones, which branch ...

the primary characteristic of this disease is the selective degeneration of upper and lower motor neurons, initiating in mid-adult life and almost invariably progressing to paralysis and death ...

Research carried out for several years with a group of patients with lower body paralysis, led by Grégoire ... the improvement in motor skills persists even without further electrical stimulation.