In the alternate pathway initiated ... play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside ...

As discussed above, 2 separate pathways play major roles in DSB repair in mammalian ... homology-directed repair is significantly impaired. Homologous integration of transfected DNA is also reduced.

The team showed that blocking homologous recombination changed the way the ... depends on the engagement of specific DNA ...

Figure 1. Points of control by human RecQ helicases in DSB repair pathway choice. HR, homologous recombination; NHEJ, non-homologous end joining; Alt-NHEJ, alternative nonhomologous end joining.

Gene conversion is often associated with a nearby cross over, which suggests that these two events are the products of the same recombination pathway ... pairing of homologous genomes at meiosis ...

1998 Homology-directed repair is a major double-strand break repair pathway in mammalian cells ... 1999 Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination.