In the alternate pathway initiated ... play a role in preventing recombination during DNA replication when it is not needed. An alternate hypothesis proposes that homologous chromosomes reside ...

As discussed above, 2 separate pathways play major roles in DSB repair in mammalian ... homology-directed repair is significantly impaired. Homologous integration of transfected DNA is also reduced.

LTRN A May 5th press release indicated that the FDA cleared Lantern Pharma, Inc.’s (NASDAQ:LTRN) LP-184 trial in triple ...

The team showed that blocking homologous recombination changed the way the ... depends on the engagement of specific DNA ...

Figure 1. Points of control by human RecQ helicases in DSB repair pathway choice. HR, homologous recombination; NHEJ, non-homologous end joining; Alt-NHEJ, alternative nonhomologous end joining.

1998 Homology-directed repair is a major double-strand break repair pathway in mammalian cells ... 1999 Mammalian XRCC2 promotes the repair of DNA double-strand breaks by homologous recombination.

Novel RBM39 molecular glue achieves complete tumor regression in mechanism-based Ewing sarcoma models; IND filing expected ...

V(D)J recombination allows the vertebrate immune system to generate a diverse array of antigen receptors. Because this process introduces double-strand DNA breaks millions of times each day, it is ...

Companies including AstraZeneca and Merck KGaA are studying forms of synthetic lethality beyond the homologous recombination deficiency pathway targeted by PARP drugs. Tessellate has found a ...

The firm will test LP-184 as a monotherapy and in combination with a PARP inhibitor in patients who have DNA damage repair gene mutations.