To address this problem, antibody engineers introduced a serine-to-proline substitution that made the middle hinge region more like that found in IgG1 (ref. 7). This not only gave a more ...

For outsourcing therapeutic antibody discovery ... mouse monoclonal antibodies comprising fully human Fab and upper hinge regions and mouse middle hinge and Fc regions. Optimized constant domains ...

This finding raises the question: can a longer stem (called hinge) on the antibody enhance mobility and thus improve its signaling capacity to immune cells? One way to investigate this is to study ...