Despite progress in defining functional elements of noncoding DNA, it is still not fully understood. Researchers, using an experiment that elucidated the function of tens of thousands of noncoding ...

Non-coding DNA is essential for both humans and trypanosomes, despite the large evolutionary divergence between these two species.

A study published in the Proceedings of the National Academy of Sciences has uncovered new clues to why some therapeutic proteins are so difficult to manufacture. The work—led by Nathan Lewis, PhD, ...

When we think about the blueprint of life, we tend to focus on DNA—the genetic code stored in every cell of our bodies. But DNA is only part of the story. For those instructions to matter, they must ...

Mammalian cell culture is and will remain the principle vehicle for protein production in upstream manufacturing, according to Florian Wurm, Ph.D., professor of biochemistry at the University of ...

Researchers have developed a novel method for controlling the precise amount of protein produced by mammalian cells. A recent research effort from the Massachusetts Institute of Technology (MIT; MA, ...

The host cell system is a critical determinant of recombinant protein quality and yield, with direct influence on protein folding and post-translational modification factors that shape the ...