The Arizona Cardinals are searching for answers after a second straight embarrassing loss to an NFC West rival.

The San Francisco 49ers had huge plays on both sides of the ball to earn a blowout win over the Arizona Cardinals. Here are the highlights.

The "49ers Postgame Live" crew highlights George Kittle's play in San Francisco's 41-22 win over the Arizona Cardinals on Sunday at State Farm Stadium.49ers star George Kittle reaches TD milestone with two-score game vs.

Brock Purdy returned from a six-game absence to throw three touchdowns as the 49ers (7-4) romped to a 41-22 win over the host Cardinals (3-7).

Coach Liam Coen insists his Jacksonville Jaguars play better when they’re angry. It was an easy emotion to harness after the biggest collapse in franchise history.

San Francisco 49ers wide receiver Skyy Moore opens the game against the Arizona Cardinals with a 98-yard kick return.

Bam Knight is active for the Arizona Cardinals' Week 11 game against the San Francisco 49ers and will likely lead the backfield, as he has recently.

The Niners are missing Nick Bosa, Fred Warner, Brandon Aiyuk, and seemingly countless others. The Cardinals will suit up without Marvin Harrison Jr. and Will Johnson. It sets this game up to be gritty and emotional, but both teams still have plenty of good players and Pro Bowl talents.