[Mahajan A, et al. Antiarrhythmic Drugs. 2011;5a] Class IC drugs block cardiac sodium channels and have no effect on the action potential. Class IC drugs are commonly used to maintain sinus rhythm ...

Propafenone, a Class 1C antiarrhythmic drug, has local anesthetic effects ... of the monophasic action potential. In Purkinje fibers, and, to a lesser extent, myocardial fibers, propafenone ...

A premature ventricular contraction occurs when a focus in the ventricle generates an action potential before ... If symptomatic, beta-blockers or antiarrhythmic drugs can be effective.

FDA extended the aficamten decision deadline to Dec. 26 after classifying the REMS submission as a major amendment to the NDA review.