This is a study led by Héctor Peinado, head of the CNIO's Microenvironment and Metastasis Group, conducted in animal models of triple-negative breast cancer that develop lung metastasis.

With this mda-9 mice model, Fisher and his team observed how MDA-9 affected the surrounding tumor microenvironment. The team developed a cell line with a propensity to form bone metastases. The ...

"Our early results show that the cells are not just surviving but, creating a realistic bone-like environment that we can use for studying cancer metastasis ... all while reducing our reliance on ...

While these events occur far from the eventual site of bone metastasis formation, they are critical steps in the metastatic process that impose significant selective pressure on tumor cells.

Researchers at the Spanish National Cancer Research Center (CNIO) have now provided new data by discovering that a high-fat diet activates mechanisms that facilitate metastasis. For cancer to ...