A full-size IgG antibody is a Y-shaped complex of two identical light chains, each with a variable and constant domain, and two heavy chains, each with one variable and three constant domains.

For example, secondary antibodies that react with IgG (H+L) will react with epitopes on both heavy and light chains, so they will react with other isotypes of primary antibody or different subtypes of ...

with optimized heavy-light chain pairing, that streamline bispecific antibody engineering and increase hit rates through an expanded antibody repertoire. "We are excited to partner with the ...

A study published in Human Gene Therapy has involved the generation of a human monoclonal antibody (mAb) directed against human eosinophils. The heavy and light chains of that fully human anti ...

“Building on Novimmune’s long experience in antibody discovery and development ... a production cell expresses a single heavy chain, alongside κ and λ light chains, which self-assemble ...

Invenra Inc., a pioneer in multispecific antibody discovery and development, announces the launch of its T-Body™ trispecific antibody platform, a next-generation technology designed to reliably direct ...

This is accomplished by including two fixed light chain options, with optimized heavy-light chain pairing, that streamline bispecific antibody engineering and increase hit rates through an expanded ...