WASHINGTON—Centrist Sen. Thom Tillis (R., N.C.) said he won’t seek re-election in 2026, less than 24 hours after he voted against a motion to advance President Trump’s tax and spending megabill, drawing public backlash from the president.

North Carolina Sen. Thom Tillis will not seek reelection after President Donald Trump threatened to seek a support a primary challenger.

Republican Sen. Thom Tillis of North Carolina said Sunday he will not seek reelection, a day after announcing his opposition to President Donald Trump’s tax breaks and spending cuts package because of its reductions to health care programs.